Comparative automated assay of anti-P1 antibodies in acute hepatic distomiasis (fascioliasis) and in hydatidosis

An automated assay of anti-P1 allohemagglutinins has been carried out on 133 P2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti-P1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individu...

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Bibliographic Details
Published inVox sanguinis Vol. 38; no. 3; p. 165
Main Authors Ben-Ismail, R, Rouger, P, Carme, B, Gentilini, M, Salmon, C
Format Journal Article
LanguageEnglish
Published England 01.01.1980
Subjects
Autoanalysis
Blood Group Antigens
Echinococcosis - blood
Echinococcosis - immunology
Fascioliasis - blood
Fascioliasis - immunology
Humans
Isoantibodies - immunology
P Blood-Group System
Phenotype
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Summary:An automated assay of anti-P1 allohemagglutinins has been carried out on 133 P2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti-P1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individuals. When compared to a reference serum test (anti-P1 standard), their concentration was found to be weak in healthy subjects, moderate in hydatidosis and exceptionally increased in acute distomiasis (up to 5-6 times the standard anti-P1 level). The 2-mercaptoethanol treatment showed that even the increased distomatid anti-P1 sera were of an IgM nature. The respective origin, synthesis and strength of these allohemagglutinins are discussed and the advantages of using distomatid IgM anti-P1 as human sera test are emphasized.
ISSN:0042-9007
DOI:10.1111/j.1423-0410.1980.tb02345.x