The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series

Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years, understanding its biological functions--originally...

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Bibliographic Details
Published inEMBO reports Vol. 9; no. 11; pp. 1094 - 1100
Main Authors Hakmé, Antoinette, Wong, Heng-Kuan, Dantzer, Françoise, Schreiber, Valérie
Format Journal Article
LanguageEnglish
Published England Springer Nature B.V 01.11.2008
Nature Publishing Group
Subjects
Adenosine diphosphate
Animals
Biosynthesis
Deoxyribonucleic acid
DNA
Humans
Nucleic acids
Poly Adenosine Diphosphate Ribose - metabolism
Poly(ADP-ribose) Polymerases - metabolism
Protein Processing, Post-Translational
Review
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Summary:Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years, understanding its biological functions--originally thought to be only the regulation of chromatin superstructure when DNA is broken--is still the subject of intense research. Here, we review the mechanisms controlling the biosynthesis of this complex macromolecule and some of its main biological functions, with an emphasis on the most recent advances and hypotheses that have developed in this rapidly growing field.
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ISSN:1469-221X
1469-3178
1469-3178
DOI:10.1038/embor.2008.191