Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-we...
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Published in | American journal of neuroradiology : AJNR Vol. 24; no. 9; pp. 1887 - 1890 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oak Brook, IL
Am Soc Neuroradiology
01.10.2003
American Society of Neuroradiology |
Subjects | |
Online Access | Get full text |
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Summary: | We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate. |
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ISSN: | 0195-6108 1936-959X |