Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study

A sequential study was performed to investigate the occurrence of cell death in preneoplastic and neoplastic liver cells of F-344 rats. The animals were administered a single initiator dose of 1,2-dimethylhydrazine and were then subjected to a liver carcinogenesis promotion regimen, consisting of a...

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Published inThe American journal of pathology Vol. 116; no. 3; pp. 441 - 446
Main Authors Columbano, A, Ledda-Columbano, GM, Rao, PM, Rajalakshmi, S, Sarma, DS
Format Journal Article
LanguageEnglish
Published Bethesda, MD ASIP 01.09.1984
American Society for Investigative Pathology
Subjects
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Carcinogens
Cell Survival
Dimethylhydrazines
Experimental digestive system and abdominal tumors
Liver - pathology
Liver Neoplasms - chemically induced
Liver Neoplasms - pathology
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - pathology
Male
Medical sciences
Orotic Acid
Precancerous Conditions - chemically induced
Precancerous Conditions - pathology
Rats
Rats, Inbred F344
Tumors
Pathology
Carcinogen
Vertebrata
Mammalia
Premalignant lesion
Rat
Cell death
Liver
Rodentia
Digestive diseases
Hepatobiliary disease
Experimental tumor
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Summary:A sequential study was performed to investigate the occurrence of cell death in preneoplastic and neoplastic liver cells of F-344 rats. The animals were administered a single initiator dose of 1,2-dimethylhydrazine and were then subjected to a liver carcinogenesis promotion regimen, consisting of a diet containing 1% orotic acid. Cell death, morphologically similar to that described as apoptosis, was evident in foci of preneoplastic hepatocytes at 10 weeks after orotic acid feeding. An increased frequency of apoptotic bodies was observed in nodules, but not in the surrounding liver, 20 weeks after starting the dietary regimen, and in hepatocellular carcinomas that developed after 1 year of continuous promotion. Occurrence of this type of cell death was also observed in liver foci of rats subjected to two other promoting regimens, suggesting, thus, a possible relevance of apoptosis to the carcinogenic process in the liver.
ISSN:0002-9440
1525-2191