Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone

Amyloid deposition is a very typical alteration in the islets of Langerhans in human Type 2 (non-insulin-dependent) diabetes mellitus and in feline diabetes mellitus. Amyloid infiltration is also commonly found in insulin-producing pancreatic tumors. It was shown recently that amyloid purified from...

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Published inThe American journal of pathology Vol. 127; no. 3; pp. 414 - 417
Main Authors Westermark, P, Wernstedt, C, O'Brien, TD, Hayden, DW, Johnson, KH
Format Journal Article
LanguageEnglish
Published Bethesda, MD ASIP 01.06.1987
American Society for Investigative Pathology
Subjects
Amino Acid Sequence
Amyloid - metabolism
Animals
Biological and medical sciences
Calcitonin - metabolism
Cat Diseases - metabolism
Cats
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - veterinary
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Humans
Islet Amyloid Polypeptide
Islets of Langerhans - metabolism
Medical sciences
Endocrinopathy
Fissipedia
Carnivora
Insulinoma
Peptide hormone
Non insulin dependent diabetes
Hypothetic hormone
Vertebrata
Mammalia
Polypeptide
Adult animal
Cat
Tumor
Amyloid
Langerhansian islet
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Summary:Amyloid deposition is a very typical alteration in the islets of Langerhans in human Type 2 (non-insulin-dependent) diabetes mellitus and in feline diabetes mellitus. Amyloid infiltration is also commonly found in insulin-producing pancreatic tumors. It was shown recently that amyloid purified from an insulinoma was composed mainly of a novel polypeptide (insulinoma amyloid polypeptide, IAPP), which had partial identity with the neuropeptide calcitonin gene-related peptide (CGRP). Cat islet amyloid contained a similar polypeptide. This finding is verified in the present study, and it is shown that the cat IAPP differs from the human peptide only in two of the 16 elucidated amino acid residues. The authors now also show by N-terminal amino acid sequence analysis that human islet amyloid is of IAPP origin. Although the significance of IAPP is unknown, its occurrence in pancreatic endocrine tissue and partial identity with a known neuropeptide suggests an endocrine regulatory function.
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ISSN:0002-9440
1525-2191