Ultrastructural alterations in the atrial myocardium of pigs with acute monensin toxicosis

Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atri...

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Bibliographic Details
Published inThe American journal of pathology Vol. 114; no. 3; pp. 367 - 379
Main Authors Van Vleet, JF, Ferrans, VJ
Format Journal Article
LanguageEnglish
Published Bethesda, MD ASIP 01.03.1984
American Society for Investigative Pathology
Subjects
Acute Disease
Animals
Biological and medical sciences
Cardiomyopathies - chemically induced
Cardiomyopathies - pathology
Cardiomyopathies - physiopathology
Cattle
Dose-Response Relationship, Drug
Drug toxicity and drugs side effects treatment
Female
Furans - toxicity
Heart Atria - drug effects
Heart Atria - pathology
Heart Atria - ultrastructure
Macrophages - pathology
Macrophages - ultrastructure
Male
Medical sciences
Monensin - toxicity
Myocardial Contraction - drug effects
Myocardium - pathology
Myocardium - ultrastructure
Necrosis
Pharmacology. Drug treatments
Swine
Toxicity: cardiovascular system
Heart
Toxicity
Oral administration
Electron microscopy
Necrosis
Pig
Pathology
Vertebrata
Antibiotic
Mammalia
Etiology
Ultrastructure
Animal
Heart disease
Myocardium
Artiodactyla
Ionophore
Ungulata
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Summary:Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atrial lesions. On days 1-4, extensive necrosis with contraction bands was present. Rapid macrophagic invasion and phagocytosis of sarcoplasmic debris was seen on days 2 and 4. Missing necrotic myocytes were outlined by persistent "tubes" of external laminas. In some surviving myocytes, sublethal injury was evident on day 1 by mitochondria with condensed conformation and on days 2, 4, and 16 by moderate to marked myofibrillar lysis and sarcoplasmic vacuolation. Monensin cardiotoxicity in pigs constitutes a unique example of selective injury to atrial myocardium.
ISSN:0002-9440
1525-2191