Diffusion-weighted MR Imaging in a Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

In a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), both T2- and diffusion-weighted MR imaging revealed lesions as hyperintense areas in the occipital lobes early after strokelike episodes. In these lesions, no significant reduction in apparent...

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Published inAmerican journal of neuroradiology : AJNR Vol. 22; no. 2; pp. 269 - 272
Main Authors Yonemura, Kiminobu, Hasegawa, Yasuhiro, Kimura, Kazumi, Minematsu, Kazuo, Yamaguchi, Takenori
Format Journal Article
LanguageEnglish
Published Oak Brook, IL Am Soc Neuroradiology 01.02.2001
American Society of Neuroradiology
Subjects
Adult
Biological and medical sciences
Brain
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
MELAS Syndrome - complications
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Stroke - diagnosis
Stroke - etiology
Human
Cartography
Stroke
Male
Nuclear magnetic resonance imaging
Differential diagnostic
Case study
Ischemia
Encephalopathy
Medical imagery
Adult
Mitochondrial myopathy
Diffusion coefficient
Diffusion
MELAS syndrome
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Summary:In a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), both T2- and diffusion-weighted MR imaging revealed lesions as hyperintense areas in the occipital lobes early after strokelike episodes. In these lesions, no significant reduction in apparent diffusion coefficient was noted. Apparent diffusion coefficient mapping may help to differentiate strokelike episodes in MELAS from acute ischemic stroke. The strokelike episodes may be related to vasogenic edema and hyperperfusion, which were suggested by our single-photon emission CT and MR imaging studies.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0195-6108
1936-959X