Metabolic Gene Polymorphism Frequencies in Control Populations

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 10; no. 12; pp. 1239 - 1248
• Main Authors: GARTE, Seymour, GASPARI, Laura, BOUCHARDY, Christine, BRESKVAR, Katja, BROCKMOLLER, Jurgen, CASCORBI, Ingolf, CLAPPER, Margie L, COUTELLE, Christiane, DALY, Ann, DELL, Marco, DOLZAN, Vita, DRESLER, Carolyn M, ALEXANDRIE, Anna-Karin, FRYER, Anthony, HAUGEN, Aage, HEIN, David W, HILDESHEIM, Allan, HIRVONEN, Ari, HSIEH, Ling-Ling, INGELMAN-SUNDBERG, Magnus, KALINA, Ivan, DAEHEE KANG, KIHARA, Masahiro, AMBROSONE, Christine, KIYOHARA, Chikako, KREMERS, Pierre, LAZARUS, Philip, LE MARCHAND, Loïc, LECHNER, Maria Celeste, VAN LIESHOUT, Ester M. M, LONDON, Stephanie, MANNI, Johannes J, MAUGARD, Christine M, MORITA, Shunji, AUTRUP, Herman, NAZAR-STEWART, Valle, NODA, Kazumasa, ODA, Yoshio, PARI, Fritz F, PASTORELLI, Roberta, PERSSON, Irene, PETERS, Wilbert H. M, RANNUG, Agneta, REBBECK, Timothy, RISCH, Angela, AUTRUP, Judith L, ROELANDT, Liliane, ROMKES, Marjorie, RYBERG, David, SALAGOVIC, Jan, SCHOKET, Bernadette, SEIDEGARD, Janeric, SHIELDS, Peter G, SIM, Edith, SINNET, Daniel, STRANGE, Richard C, BARANOVA, Helena, BATHUM, Lise, BENHAMOU, Simone, BOFFETTA, Paolo
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2001
• Subjects: Biological and medical sciences; Black or African American; Black People - genetics; Cytochrome P-450 Enzyme System - genetics; Databases, Factual; Gene Frequency; General aspects; Genetic Linkage; Genetic Predisposition to Disease; Humans; Medical sciences; Neoplasms - genetics; Polymorphism, Genetic; Tumors; White People - genetics; Human; Metabolism; Carcinogenesis; Population genetics; Allele; Health and environment; Enzymatic activity; Gene frequency; Gene; Genetics; Population; Public health; Polymorphism
• ISSN: 1055-9965; 1538-7755

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes ( CYP1A1 , CYP2E1 , CYP2D6 , GSTM1 , GSTT1 , NAT2 , GSTP , and EPHX ) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians ( n = 12,525), Asians ( n = 2,136), and Africans and African Americans ( n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.