The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma

• Published in: Cancer research (Chicago, Ill.) Vol. 59; no. 22; pp. 5662 - 5665
• Main Authors: QIN, L.-X, TANG, Z.-Y, SHAM, J. S. T, MA, Z.-C, YE, S.-L, ZHOU, X.-D, WU, Z.-Q, TRENT, J. M, GUAN, X.-Y
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.1999
• Subjects: Adult; Aged; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - secondary; Chromosome 1; Chromosome 17; Chromosome 19; Chromosome 4; Chromosome 5; Chromosome 8; Chromosome Deletion; Chromosomes, Human, Pair 1 - genetics; Chromosomes, Human, Pair 8 - genetics; Disease Progression; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Tumors; Chromosomal aberration; Human; Tumoral tissue; Hepatic disease; Hepatocellular carcinoma; Malignant tumor; Metastasis; Chromosome C8; Tumor progression; Deletion; Digestive diseases; Abnormal chromosome; Genetics; Advanced stage; Mechanism of action
• ISSN: 0008-5472; 1538-7445

To understand the genetic mechanisms underlying the progression of hepatocellular carcinoma (HCC) metastasis, differences of genomic alterations between 10 pairs of primary HCC tumors and their matched metastatic lesions were analyzed by comparative genomic hybridization. Several chromosomal alterations including loss of 8p, 4q, 17p, and 19p, gain of 5p and high-level amplification of 1q12-q22 were detected in two or more cases. The most significant finding is the loss of 8p which was detected in 8 metastatic tumors but only in 3 corresponding primary tumors (P = 0.03). This result suggests that the deletion of chromosome 8p might contribute to the development of HCC metastasis. Another interesting result is the detection of a minimum high-level amplification region at 1q12-q22 in HCC. This result provides a candidate amplification region in HCC for further study to identify amplified oncogenes related to the development or progression of HCC. Finally, this study provides a practicable model to detect specific genetic alterations related to the tumor metastasis through comparing the primary tumor and its corresponding metastatic lesion using comparative genomic hybridization technique.