Induction of pituitary tumors in germ-free rats exposed to Aspergillus versicolor

• Published in: Cancer research (Chicago, Ill.) Vol. 50; no. 2; pp. 400 - 402
• Main Authors: SUMI, Y, NAGURA, H, MIYAKAWA, M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.01.1990
• Subjects: Adenoma - etiology; Adenoma - pathology; Animals; Aspergillus - pathogenicity; Biological and medical sciences; Endocrinopathies; Germ-Free Life; Hypothalamus. Hypophysis. Epiphysis (diseases); Medical sciences; Mycotoxins - toxicity; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pituitary Neoplasms - etiology; Pituitary Neoplasms - pathology; Rats; Rats, Inbred Strains; Endocrinopathy; Aspergillus versicolor; Rat; Pathogenesis; Rodentia; Adenoma; Fungi; Vertebrata; Experimental disease; Mammalia; Animal; Pituitary diseases; Tumor; Fungi Imperfecti; Thallophyta

We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of...