Induction of pituitary tumors in germ-free rats exposed to Aspergillus versicolor

We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 50; no. 2; pp. 400 - 402
Main Authors SUMI, Y, NAGURA, H, MIYAKAWA, M
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.01.1990
Subjects
Adenoma - etiology
Adenoma - pathology
Animals
Aspergillus - pathogenicity
Biological and medical sciences
Endocrinopathies
Germ-Free Life
Hypothalamus. Hypophysis. Epiphysis (diseases)
Medical sciences
Mycotoxins - toxicity
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Neoplasms - etiology
Pituitary Neoplasms - pathology
Rats
Rats, Inbred Strains
Endocrinopathy
Aspergillus versicolor
Rat
Pathogenesis
Rodentia
Adenoma
Fungi
Vertebrata
Experimental disease
Mammalia
Animal
Pituitary diseases
Tumor
Fungi Imperfecti
Thallophyta
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Summary:We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassociated rats had pituitary tumors (62.3%), while only three of the 41 control germ-free rats had tumors (7.3%). It seems likely that this high incidence of pituitary tumor in the experimental rats is due to metabolites derived from the mold.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0008-5472
1538-7445