Feline lymphomas: immunological and cytochemical characterization

The immunological and cytochemical phenotypes of five primary feline lymphomas and six feline lymphoma lines are reported. Thymic lymphomas induced by the Rickard strain of FeLV (FeLV-R) are of prothymocyte or (immature) cortical thymocyte origin, as these express terminal deoxynucleotidyl transfera...

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Published inCancer research (Chicago, Ill.) Vol. 49; no. 2; pp. 345 - 351
Main Authors ROJKO, J. L, KOCIBA, G. J, ABKOWITZ, J. L, HAMILTON, K. L, HARDY, W. D. JR, IHLE, J. N, O'BRIEN, S. J
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.01.1989
Subjects
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Bone Marrow - microbiology
Bone Marrow Cells
Cat Diseases - immunology
Cat Diseases - pathology
Cats
Cell Line
Experimental malignant blood diseases
Guinea Pigs
Immunohistochemistry
Interleukin-2 - biosynthesis
Leukemia Virus, Feline
Lymphoma - veterinary
Medical sciences
Rosette Formation
Tumors
Fissipedia
Carnivora
Vertebrata
Phenotype
Mammalia
Immunocytochemistry
Malignant hemopathy
Monoclonal antibody
Lymphoma
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Summary:The immunological and cytochemical phenotypes of five primary feline lymphomas and six feline lymphoma lines are reported. Thymic lymphomas induced by the Rickard strain of FeLV (FeLV-R) are of prothymocyte or (immature) cortical thymocyte origin, as these express terminal deoxynucleotidyl transferase, the guinea pig erythrocyte rosette receptor, Ia antigens, partial cortisone sensitivity, and nonspecific esterase. Lymphomas associated with other strains of FeLV form rosettes with guinea pig erythrocytes, frequently have Ia antigens and cytoplasmic nonspecific esterase, and probably originate from helper T-cells, monocyte/macrophages, or null cells. These data belie previous conclusions that FeLV leukemogenesis is restricted to mature T-cells; rather, the considerable heterogeneity in the surface and cytochemical phenotype of feline lymphomas probably reflects transformation of multipotent lymphoid or monocytoid precursors in the bone marrow by FeLV.
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ISSN:0008-5472
1538-7445