A Double TRPtych: Six Views of Transient Receptor Potential Channels in Disease and Health

• Published in: The Journal of neuroscience Vol. 28; no. 46; pp. 11778 - 11784
• Main Authors: Cornell, Robert A, Aarts, Michelle, Bautista, Diana, Garcia-Anoveros, Jaime, Kiselyov, Kirill, Liman, Emily R
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 12.11.2008; Society for Neuroscience
• Series: Mini-Symposium
• Subjects: Animals; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Deafness - genetics; Deafness - metabolism; Deafness - physiopathology; Genetic Predisposition to Disease - genetics; Humans; Lysosomal Storage Diseases, Nervous System - genetics; Lysosomal Storage Diseases, Nervous System - metabolism; Lysosomal Storage Diseases, Nervous System - physiopathology; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nerve Degeneration - physiopathology; Nervous System - metabolism; Nervous System - physiopathology; Nervous System Diseases - genetics; Nervous System Diseases - metabolism; Nervous System Diseases - physiopathology; Pain - genetics; Pain - metabolism; Pain - physiopathology; Symposia and Mini-Symposia; Transient Receptor Potential Channels - genetics; Transient Receptor Potential Channels - metabolism
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.3929-08.2008

At the 2008 Annual Meeting of the Society for Neuroscience, a Mini-Symposium entitled "Contributions to TRP Channels to Neurological Disease" included talks from six heads of newly established laboratories, each with a unique research focus, model system, and set of experimental tools. Some of the questions addressed in these talks include the following. What is the role of transient receptor potential (TRP) channels in pain perception? How do normally functioning TRP channels contribute to cell death pathways? What are the characteristics of TRPpathies, disease states that result from overactive or underactive TRP channels? How are TRP channels regulated by signal transduction cascades? This review summarizes recent results from those laboratories and provides six perspectives on the subject of TRP channels and disease.