Hormonal control of the expression of antibody-defined lactosaminoglycans in the mouse uterus
The uterus undergoes a number of hormone-induced changes during estrus and early pregnancy. Changes in the uterine glycoprotein population have been investigated by using the monoclonal antibodies SSEA-1, IIC 3, A5, and C6. These antibodies detect specific terminal or side-chain modifications of lac...
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Published in | Biology of reproduction Vol. 39; no. 3; pp. 699 - 706 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Madison, WI
Society for the Study of Reproduction
01.10.1988
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Subjects | |
Online Access | Get full text |
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Summary: | The uterus undergoes a number of hormone-induced changes during estrus and early pregnancy. Changes in the uterine glycoprotein
population have been investigated by using the monoclonal antibodies SSEA-1, IIC 3, A5, and C6. These antibodies detect specific
terminal or side-chain modifications of lactosaminoglycan molecules. In ovariectomized female mice treated with estrogen,
SSEA-1 was the only antigen expressed at the uterine epithelium. Progestational stimuli for 2 days induced SSEA-1 expression
in the uterine glands and the sialylated form of A5 at the uterine epithelium. Three days of progesterone treatment induced
IIC3 expression within the uterine glands. An additional day of progesterone treatment resulted in a uterine epithelial expression
of IIC3. The expression of these antigens in the progestational phase were confirmed in naturally mated females. In these
preparations, expression of the sialylated form of C6 was also observed, beginning on Day 2.0 of gestation. These observations
suggest subtle modification of lactosaminoglycan chains during the hormonally induced preparative and receptive phases of
the mouse uterus. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0006-3363 1529-7268 |
DOI: | 10.1095/biolreprod39.3.699 |