Radioimmune Imaging of Bone Marrow in Patients with Suspected Bone Metastases from Primary Breast Cancer

• Published in: The Journal of nuclear medicine (1978) Vol. 31; no. 9; pp. 1450 - 1455
• Main Authors: Duncker, Carlos M, Carrio, Ignasi, Berna, Lluis, Estorch, Montserrat, Alonso, Carmen, Ojeda, Belen, Blanco, Remei, Germa, Josep-Ramon, Ortega, Victoria
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.09.1990; Society of Nuclear Medicine
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; ANIMAL TISSUES; ANTIBODIES; Antibodies, Monoclonal; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; Biological and medical sciences; BODY; BONE MARROW; Bone Marrow - diagnostic imaging; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - secondary; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging; Carcinoma, Intraductal, Noninfiltrating - secondary; COUNTING TECHNIQUES; DIAGNOSIS; DIAGNOSTIC TECHNIQUES; DISEASES; Female; GLANDS; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; Humans; INTERMEDIATE MASS NUCLEI; Investigative techniques, diagnostic techniques (general aspects); ISOMERIC NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMARY GLANDS; Medical sciences; METASTASES; Middle Aged; MONOCLONAL ANTIBODIES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; Osteoarticular system. Muscles; PATIENTS; RADIOIMMUNODETECTION; RADIOIMMUNOSCINTIGRAPHY; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; Radionuclide investigations; SCINTISCANNING; SKELETON; Technetium; TECHNETIUM 99; TECHNETIUM ISOTOPES; TISSUES; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES; Radionuclide study; Human; Mammary gland diseases; Radiolabelling; Granulocyte; Diseases of the osteoarticular system; Bone marrow; Monoclonal antibody; Metastasis; Immunoradiodiagnosis
• ISSN: 0161-5505; 1535-5667

Radioimmune imaging of bone marrow was performed by technetium-99m- (99mTc) labeled antigranulocyte monoclonal antibody BW 250/183 (AGMoAb) scans in 32 patients with suspected bone metastases from primary breast cancer. AGMoAb scans showed bone marrow defects in 25/32 (78%) patients; bone invasion was subsequently confirmed in 23 (72%) patients. Conventional bone scans performed within the same week detected bone metastases in 17/32 (53%) patients (p less than 0.001). AGMoAb scans detected more sites indicating metastatic disease than bone scans in 12 of these 17 patients (71%). All patients with bone metastases in the axial skeleton had bone marrow defects at least at the sites of bone metastases. Of 15 patients with normal, or indicative of, benign disease bone scans, 8 patients (53%) presented with bone marrow defects in the AGMoAb scans. Bone invasion was confirmed in six of them. AGMoAb bone marrow scans provide a method for the early detection of bone metastatic invasion in patients with breast cancer and suspected bone metastases.