Immunocytochemical localization of parathyroid hormone in bovine parathyroid glands and human parathyroid adenomas

Light and electron microscopic localization of parathyroid hormone (PTH) in human and bovine parathyroid tissue has been achieved using an indirect peroxidase labeled antibody method. Granular deposition of the reaction product was found throughout the chief cell cytoplasm. There was no nuclear stai...

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Bibliographic Details
Published inThe American journal of pathology Vol. 94; no. 3; pp. 615 - 622
Main Authors Futrell, JM, Roth, SI, Su, SP, Habener, JF, Segre, GV, Potts, JT, Jr
Format Journal Article
LanguageEnglish
Published United States ASIP 01.03.1979
Subjects
Adenoma - analysis
Adenoma - ultrastructure
Animals
Cattle
Fluorescent Antibody Technique
Humans
Male
Parathyroid Glands - analysis
Parathyroid Glands - ultrastructure
Parathyroid Hormone - analysis
Parathyroid Neoplasms - analysis
Parathyroid Neoplasms - ultrastructure
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Summary:Light and electron microscopic localization of parathyroid hormone (PTH) in human and bovine parathyroid tissue has been achieved using an indirect peroxidase labeled antibody method. Granular deposition of the reaction product was found throughout the chief cell cytoplasm. There was no nuclear staining. At the ultrastructural level, parathyroid hormone localized by this method appeared to be largely confined to the secretory granules in the cytoplasm of cells. Mitochondria and nuclei were free of reaction product. Aggregated sacs of granular endoplasmic reticulum were minimally reactive, and Golgi apparatuses did not show reaction product.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9440
1525-2191