Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5

• Published in: Molecular and Cellular Biology Vol. 17; no. 5; pp. 2933 - 2943
• Main Authors: Matsumura, I, Ishikawa, J, Nakajima, K, Oritani, K, Tomiyama, Y, Miyagawa, J, Kato, T, Miyazaki, H, Matsuzawa, Y, Kanakura, Y
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.05.1997
• Subjects: Antimetabolites, Antineoplastic - pharmacology; Carrier Proteins - metabolism; Cell Cycle Proteins; Cell Differentiation - drug effects; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins - metabolism; Cytarabine - pharmacology; DNA-Binding Proteins - metabolism; Enzyme Inhibitors - metabolism; Genes, Tumor Suppressor; Humans; Leukemia, Megakaryoblastic, Acute - pathology; Microtubule-Associated Proteins - metabolism; Milk Proteins; Protein Kinase Inhibitors; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate - pharmacology; Thrombopoietin - pharmacology; Trans-Activators - metabolism; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins
• ISSN: 0270-7306; 1098-5549
• DOI: 10.1128/MCB.17.5.2933

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