Significant Association of DNA Repair Gene Ku80 Genotypes with Breast Cancer Susceptibility in Taiwan

• Published in: Anticancer research Vol. 29; no. 12; pp. 5251 - 5254
• Main Authors: Wang, Hwei-Chung, Liu, Chiu-Shong, Chiu, Chang-Fang, Chiang, Su-Yin, Wang, Chung-Hsing, Wang, Rou-Fen, Lin, Cheng-Chieh, Tsai, Ru-Yin, Bau, Da-Tian
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.12.2009
• Subjects: Antigens, Nuclear - genetics; Biomarkers, Tumor - genetics; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Case-Control Studies; DNA Repair - genetics; DNA-Binding Proteins - genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Ku Autoantigen; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Prognosis; Taiwan

Aim: To evaluate the association between the genotypes of the heterodimeric DNA-binding component, Ku80 gene and the breast cancer risk in Taiwan. Patients and Methods: In this hospital-based case-control study, the association of Ku80 G-1401T rs828907, Ku80 C-319T rs11685387 and Ku80 intron19 rs928...