Significant Association of DNA Repair Gene Ku80 Genotypes with Breast Cancer Susceptibility in Taiwan
Aim: To evaluate the association between the genotypes of the heterodimeric DNA-binding component, Ku80 gene and the breast cancer risk in Taiwan. Patients and Methods: In this hospital-based case-control study, the association of Ku80 G-1401T rs828907, Ku80 C-319T rs11685387 and Ku80 intron19 rs928...
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Published in | Anticancer research Vol. 29; no. 12; pp. 5251 - 5254 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
International Institute of Anticancer Research
01.12.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Aim: To evaluate the association between the genotypes of the heterodimeric DNA-binding component, Ku80 gene and the breast
cancer risk in Taiwan. Patients and Methods: In this hospital-based case-control study, the association of Ku80 G-1401T rs828907,
Ku80 C-319T rs11685387 and Ku80 intron19 rs9288518 polymorphisms with breast cancer risk in a Taiwanese population was investigated.
In total, 1272 patients with breast cancer and the same number of age- and gender-matched healthy controls were genotyped.
Results: A significantly different distribution was found in the frequency of the Ku80 G-1401T genotype, but not the Ku80
C-319T or intron 19 genotypes, between the breast cancer and control groups. The T allele Ku80 G-1401T conferred a significant
(p=0.0069) increased risk of breast cancer. Gene interactions with smoking, but not with breastfeeding, were significant for
the Ku80 G-1401T polymorphism. The Ku80 G-1401T GT and TT genotypes in association with smoking conferred an increased risk
of 3.162 (95% confidence interval=2.275-4.393) for breast cancer. Conclusion: The T allele of Ku80 G-1401T may be associated
with the development of breast cancer and may be a novel useful marker for breast cancer detection and prediction. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |