Phase II multicenter study of arsenic trioxide, ascorbic acid and dexamethasone in patients with relapsed or refractory multiple myeloma

Arsenic trioxide induces growth inhibition and apoptosis in multiple myeloma cell lines. Reducing glutathione by ascorbic acid may enhance the efficacy of arsenic trioxide. Here we report the results of an international multi-center study of arsenic trioxide in combination with ascorbic acid and dex...

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Bibliographic Details
Published inHaematologica (Roma) Vol. 91; no. 12; pp. 1722 - 1723
Main Authors Wu, KL, Beksac, M, van Droogenbroeck, J, Amadori, S, Zweegman, S, Sonneveld, P
Format Journal Article
LanguageEnglish
Published Pavia Haematologica 01.12.2006
Subjects
Adult
Aged
Arsenicals - administration & dosage
Ascorbic Acid - administration & dosage
Biological and medical sciences
Dexamethasone - administration & dosage
Drug Therapy, Combination
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Oxides - administration & dosage
Recurrence
Human
Corticosteroid
Immunopathology
Relapse
Treatment resistance
Ascorbic acid
Dexamethasone
Hematology
Steroid hormone
Multicenter study
Vitamin
Arsenic trioxide
Malignant hemopathy
Myeloma
Treatment
Immunoglobulinopathy
Lymphoproliferative syndrome
Phase II trial
Arsenic acid
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Summary:Arsenic trioxide induces growth inhibition and apoptosis in multiple myeloma cell lines. Reducing glutathione by ascorbic acid may enhance the efficacy of arsenic trioxide. Here we report the results of an international multi-center study of arsenic trioxide in combination with ascorbic acid and dexamethasone as treatment for patients with advanced multiple myeloma.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
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ObjectType-Correspondence-3
ISSN:0390-6078
1592-8721