Oligodeoxynucleotides as inhibitors of gene expression: a review

The past several years have seen an explosive growth in the application of antisense oligodeoxynucleotides as modulators of gene expression. In this review, we discuss the various classes of compounds currently receiving attention. These include unmodified oligodeoxynucleotides, methylphosphonates,...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 48; no. 10; pp. 2659 - 2668
Main Authors Stein, C A, Cohen, J S
Format Journal Article
LanguageEnglish
Published United States 15.05.1988
Subjects
Antiviral Agents - pharmacology
Gene Expression Regulation - drug effects
Humans
Neoplasms - drug therapy
Oligodeoxyribonucleotides - pharmacology
Oligodeoxyribonucleotides - therapeutic use
Organophosphorus Compounds - pharmacology
Structure-Activity Relationship
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Summary:The past several years have seen an explosive growth in the application of antisense oligodeoxynucleotides as modulators of gene expression. In this review, we discuss the various classes of compounds currently receiving attention. These include unmodified oligodeoxynucleotides, methylphosphonates, phosphorothioates, and alpha-oligonucleotides. The relative advantages and disadvantages of each class with regard to parameters such as (a) duplex stability (b) nuclease resistance, and (c) effectiveness of specific gene inhibition are noted. Oligodeoxynucleotides covalently linked to intercalating and other reactive groups are also described, as are possible mechanisms of oligodeoxynucleotide action. Finally, we consider potential future directions for this field and note that it holds the promise for specific gene therapy.
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ISSN:0008-5472
1538-7445