Antiproliferative Activity of Vitamin D Compounds in Combination with Cytostatics
Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are presented. Applying antiproliferative SRB and...
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Published in | Anticancer research Vol. 26; no. 4A; pp. 2701 - 2705 |
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Main Authors | , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Attiki
International Institute of Anticancer Research
01.07.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin
D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are
presented. Applying antiproliferative SRB and MTT assays, the growth inhibitory effects of the vitamin D compounds, applied
alone or in combination with either cisplatin or doxorubicin, were measured. The following cancer cell lines were employed:
A549 (human non-small cell lung carcinoma), B16 (murine melanoma), CCRF, HL-60 (human leukaemia), SW707 (human colon cancer),
MCF-7, T47D (human breast cancer), WEHI-3 (mouse leukaemia) and normal cells: BALB 3T3 (normal murine fibroblast cell line).
It was shown that the treatment of tumour cells, which are sensitive to vitamin D compounds, with the combination of vitamin
D compounds and cytostatics decreased the inhibitory concentration 50% (IC 50 ) values compared with the effects of the cytostatics applied alone. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |