Immunohistochemical Detection of Prostate-specific Antigen Expression in Primary Urothelial Carcinoma of the Urinary Bladder
Background: Prostate-specific antigen (PSA) is a 33-kDa serine protease that is secreted by prostatic epithelium and non-prostate tissues. Ectopic expression of PSA has also been reported in a variety of non-prostatic epithelial tumors. Patients and Methods: Expression of PSA and its clinical implic...
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Published in | Anticancer research Vol. 28; no. 6B; pp. 4149 - 4154 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Attiki
International Institute of Anticancer Research
01.11.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Background: Prostate-specific antigen (PSA) is a 33-kDa serine protease that is secreted by prostatic epithelium and non-prostate
tissues. Ectopic expression of PSA has also been reported in a variety of non-prostatic epithelial tumors. Patients and Methods:
Expression of PSA and its clinical implication were examined in a total of 422 cases of primary urothelial carcinoma of the
bladder. Results: Cytoplasmic reactivity to PSA was observed in 6 cases (1.4%), with the staining being to a low degree in
3 and a high degree in the remaining 3 cases. Expression of PSA was positively related to multiplicity, large tumors (â¥3 cm)
and muscle invasion (â¥pT2) (p=0.0008, 0.004 and 0.03, respectively). Patients with tumors of low PSA expression had a better
survival than those with tumors of high PSA expression (p=0.03). Conclusion: Focal expression of PSA can occasionally be detected
in some large, invasive urothelial cancer cells. This phenotypic change should be considered in the differential diagnosis
of poorly differentiated carcinoma of the lower urinary tract. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |