Expression of the Pantumour Thomsen-Friedenreich Antigen in the Human Placenta with the Diagnosis of Hydatidiform Mole

Background: The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope, Galβ1-3GalNAc) has long been known as a pancarcinoma antigen. Specific carrier proteins of the TF-antigen are the mucins, in particular Mucin 1. Here, we present our results of immunohistochemical identification of this...

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Bibliographic Details
Published inAnticancer research Vol. 27; no. 4A; pp. 2001 - 2003
Main Authors RICHTER, D. U, JESCHKE, U, MAKOVITZKY, J, GERBER, B, BRIESE, V
Format Journal Article Conference Proceeding
LanguageEnglish
Published Attiki International Institute of Anticancer Research 01.07.2007
Subjects
Antigens, Tumor-Associated, Carbohydrate - biosynthesis
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
Hydatidiform Mole - diagnosis
Hydatidiform Mole - metabolism
Immunohistochemistry
Medical sciences
Mucin-1 - biosynthesis
Placenta - metabolism
Pregnancy
Pregnancy. Fetus. Placenta
Tumors
Uterine Neoplasms - diagnosis
Uterine Neoplasms - metabolism
Human
Thomsen Friedenreich antigen
Trophoblaste pathology
Pregnancy disorders
Hydatidiform mole
Fetal membrane
Placenta diseases
Cancerology
Tumor
placenta
Mucin 1
Thomsen-Friedenreich antigen
Diagnosis
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Summary:Background: The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope, Galβ1-3GalNAc) has long been known as a pancarcinoma antigen. Specific carrier proteins of the TF-antigen are the mucins, in particular Mucin 1. Here, we present our results of immunohistochemical identification of this carbohydrate antigen in human placenta. Materials and Methods: Paraffin-embedded placental and decidual tissues from patients with the diagnosis hydatidiform mole were incubated with different monoclonal antibodies directed against TF-epitope (CD 176, IgM) and against Mucin 1 (CD 227, IgG). Results: No expression of the TF-antigen or of Mucin 1 (Muc 1) was found in the decidual tissues, but the samples of chorionic tissues were TF- and Muc 1-antigen positive. As positive control, placental samples of the first trimester were investigated. Conclusion: A disorder of the extra-villous trophoblast cells is present in hydatidiform mole.
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ISSN:0250-7005
1791-7530