Medullary Thyroid Carcinoma: Autologous Tumor Cell Lines for Dendritic Cell Vaccination

• Published in: Anticancer research Vol. 25; no. 6B; pp. 4225 - 4230
• Main Authors: PFRAGNER, Roswitha, SKOFITSCH, Gerhard, HÖGER, Harald, JECH, Marion, RINNER, Beate, SIEGL, Veronika, NIEDERLE, Bruno, GNANT, Michael, FRIEDL, Josef, STIFT, Anton
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.11.2005
• Subjects: Animals; Biological and medical sciences; Cancer Vaccines - immunology; Cancer Vaccines - therapeutic use; Carcinoma, Medullary - immunology; Carcinoma, Medullary - pathology; Carcinoma, Medullary - therapy; Cell Line, Tumor; Endocrinopathies; Humans; Immunotherapy, Adoptive - methods; Malignant tumors; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Nude; Thyroid Neoplasms - immunology; Thyroid Neoplasms - pathology; Thyroid Neoplasms - therapy; Thyroid. Thyroid axis (diseases); Tumors; Endocrinopathy; Dendritic cell; Cell culture; Treatment resistance; Vaccination; Thyroid diseases; Malignant tumor; Thyroid carcinoma; Prevention; autologous tumor cell cultures; Thyroid cancer; Cancerology; Treatment; dendritic cells; Antigen presenting cell; Immunotherapy; Established cell line; Medullary carcinoma; drug resistance; Tumor cell; Medullary thyroid carcinoma

Background: Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the parafollicular C-cells, accounting for 5-10% of all thyroid tumors. To date, the only effective treatment is the early and total surgical removal of all neoplastic tissue. As the prognosis of patients with advanced...