E-cadherin and Fibronectin Expressions Have No Prognostic Role in Stage II Ductal Breast Cancer

Background: The aim of the study was to describe the expressions of E-cadherin (EC) and fibronectin (FN) and their prognostic value in radically-treated ductal breast cancer. Patients and Methods: Ninety-eight patients, aged 26-86 (median, 57) with stage II G2 or G3 tumors, were subjected to a retro...

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Published inAnticancer research Vol. 25; no. 4; pp. 2879 - 2883
Main Authors SWIATONIOWSKI, Grzegorz, MATKOWSKI, Rafal, SUDER, Elzbieta, BRUZEWICZ, Szymon, SETTA, Monika, KORNAFEL, Jan, POLOZOWSKI, Andrzej, SUROWIAK, Pawel
Format Journal Article
LanguageEnglish
Published Attiki International Institute of Anticancer Research 01.07.2005
Subjects
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cadherins - biosynthesis
Carcinoma, Ductal - metabolism
Carcinoma, Ductal - pathology
Disease-Free Survival
Female
Fibronectins - biosynthesis
Humans
Immunohistochemistry
Medical sciences
Middle Aged
Neoplasm Staging
Tumors
Mammary gland diseases
ductal breast cancer
Cancerology
Prognosis
Cell adhesion molecule
Early stage
Breast cancer
Malignant tumor
E Cadherin
E-cadherin
Fibronectin
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Summary:Background: The aim of the study was to describe the expressions of E-cadherin (EC) and fibronectin (FN) and their prognostic value in radically-treated ductal breast cancer. Patients and Methods: Ninety-eight patients, aged 26-86 (median, 57) with stage II G2 or G3 tumors, were subjected to a retrospective analysis. Results: No significant associations were observed between the levels of the proteins studied and patient or cancer features, with the exception of relationships between FN expression and the histological grade of the tumor or hormonal status of the subjects. None of the markers showed a correlation with survival in multivariate analysis. Consequently, the experiment revealed no prognostic value of EC or FN expression in a homogenous patient group with stage II G2 or G3 ductal breast carcinoma. Conclusion: Further studies, on other uniform populations, with tumor features different from those described here, are necessary in order to reveal the prognostic significance of the molecules discussed.
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ISSN:0250-7005
1791-7530