Biochemical programs of slowly and rapidly growing human colon carcinoma xenografts

The purpose of this investigation was to elucidate the enzymic programs of pyrimidine, carbohydrate, and purine metabolism and the pattern of pyrimidine and purine ribonucleotides in two lines of human colon carcinoma xenografts of different growth rates. The slower-growing colon tumor line was well...

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Published inCancer research (Chicago, Ill.) Vol. 41; no. 3; pp. 854 - 859
Main Authors Weber, G, Hager, J C, Lui, M S, Prajda, N, Tzeng, D Y, Jackson, R C, Takeda, E, Eble, J N
Format Journal Article
LanguageEnglish
Published United States 01.03.1981
Subjects
Adenocarcinoma - pathology
Animals
Cell Division
Colonic Neoplasms - enzymology
Colonic Neoplasms - pathology
Glycolysis
Humans
Mice
Mice, Nude
Neoplasm Transplantation
Pentosephosphates - metabolism
Purines - metabolism
Pyrimidines - metabolism
Transplantation, Heterologous
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Summary:The purpose of this investigation was to elucidate the enzymic programs of pyrimidine, carbohydrate, and purine metabolism and the pattern of pyrimidine and purine ribonucleotides in two lines of human colon carcinoma xenografts of different growth rates. The slower-growing colon tumor line was well differentiated; the more rapidly growing line was a poorly differentiated one. The carcinoma xenografts were carried in nude (athymic) mice. The increased malignancy and growth rate of the rapidly growing colon tumor were characterized by a markedly amplified imbalance in the enzymic programs and nucleotide patterns.
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ISSN:0008-5472