Expression of an unusual isozyme of lactate dehydrogenase in the serum of cancer patients and comparison with carcinoembryonic antigen

• Published in: Cancer research (Chicago, Ill.) Vol. 47; no. 22; pp. 6156 - 6160
• Main Authors: MANLY, K. F, PETRELLI, N, ANDERSON, G. R, EMRICH, L. J, HERRERA, L, MITTELMAN, A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.1987
• Subjects: Biological and medical sciences; Biomarkers, Tumor - blood; Carcinoembryonic Antigen - analysis; Colonic Neoplasms - blood; Colonic Neoplasms - pathology; Female; Host-tumor relations. Immunology. Biological markers; Humans; Isoenzymes; L-Lactate Dehydrogenase - blood; Medical sciences; Neoplasm Metastasis; Rectal Neoplasms - blood; Rectal Neoplasms - pathology; Reference Values; Tumors; Human; Carcinoembryonic antigen; Prognosis; Isozyme; Metástasis; Lactate dehydrogenase; Serum; Tumor; Tumoral marker
• ISSN: 0008-5472; 1538-7445

Two studies reported here demonstrate a statistically significant association between metastatic cancer and the appearance of the k isozyme of lactate dehydrogenase in serum of affected patients. The first study included 190 coded samples from three types of cancer patients and matched controls; the second included 155 preoperative and 200 postoperative colorectal cancer patients. In the second, plasma carcinoembryonic antigen was compared with serum k isozyme of lactate dehydrogenase as an indicator of the presence of metastatic cancer. This comparison showed that both markers were independently useful for assessing patient status and predicted that a combination of the two should be a better discriminator for the presence of metastases than either marker alone.