Early Effects of Transplatin on Oncogene Activation In Vivo
The aim of the study was to investigate the early effect of Transplatin (the stereo-isomer of Cisplatin) on oncogenes in inbred CBA/Ca mice. Cisplatin is commonly used for the treatment of squamous cell carcinomas of the head and neck. Cisplatin has a strong oncogene activation effect compared to th...
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Published in | Anticancer research Vol. 24; no. 6; pp. 3997 - 4001 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Attiki
International Institute of Anticancer Research
01.11.2004
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Subjects | |
Online Access | Get full text |
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Summary: | The aim of the study was to investigate the early effect of Transplatin (the stereo-isomer of Cisplatin) on oncogenes in inbred
CBA/Ca mice. Cisplatin is commonly used for the treatment of squamous cell carcinomas of the head and neck. Cisplatin has
a strong oncogene activation effect compared to the structural analogue Transplatin. Body weight equivalent amounts of a human
dose of Transplatin were administered intraperitoneally to 6- to 8-week-old, inbred, female CBA/Ca mice. Twenty-four, 48 and
72 hours after the treatment, RNA was isolated from the target organs and the expressions of c-myc, Haras and p53 genes were
examined. Investigation of early changes showed no significant overexpression compared to Cisplatin, which had a significant
effect on oncogene expression in the âshort-termâ in vivo test system. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |