Nuclear structure-gene expression interrelationships : Implications for aberrant gene expression in cancer

There is long-standing recognition that transformed and tumor cells exhibit striking alterations in nuclear morphology as well as in the representation and intranuclear distribution of nucleic acids and regulatory factors. Parameters of nuclear structure support cell growth and phenotypic properties...

Full description

Saved in:
Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 60; no. 8; pp. 2067 - 2076
Main Authors STEIN, G. S, MONTECINO, M, VAN WIJNEN, A. J, STEIN, J. L, LIAN, J. B
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.04.2000
Subjects
Animals
Biological and medical sciences
Cell Nucleus - chemistry
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cell Nucleus - ultrastructure
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Chromatin - chemistry
Chromatin - genetics
Chromatin - metabolism
Chromatin - ultrastructure
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic - genetics
Genome
Humans
Molecular and cellular biology
Neoplasms - genetics
Neoplasms - pathology
Nuclear Matrix - chemistry
Nuclear Matrix - genetics
Nuclear Matrix - metabolism
Nuclear Matrix - ultrastructure
Structure-Activity Relationship
Transcription, Genetic - genetics
Chromatin
Transformed cell
Cell nucleus
Genetics
Gene organization
Review
Gene expression
Transcription factor
Carcinogenesis
Nuclear envelope
Tumor cell
Mechanism
Online AccessGet full text

Cover

More Information
Summary:There is long-standing recognition that transformed and tumor cells exhibit striking alterations in nuclear morphology as well as in the representation and intranuclear distribution of nucleic acids and regulatory factors. Parameters of nuclear structure support cell growth and phenotypic properties of cells by facilitating the organization of genes, replication and transcription sites, chromatin remodeling complexes, transcripts, and regulatory factors in structurally and functionally definable subnuclear domains within the three-dimensional context of nuclear architecture. The emerging evidence for functional interrelationships of nuclear structure and gene expression is consistent with linkage of tumor-related modifications in nuclear organization to compromised gene regulation during the onset and progression of cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0008-5472
1538-7445