Correlation of Nuclear Morphometry of Breast Cancer in Histological Sections with Clinicopathological Features and Prognosis
Background: The relation of nuclear morphometry measurements with clinicopathological features was evaluated along with prognosis in invasive female breast carcinoma in Libyan patients. Data was compared with corresponding results on Finnish, and Nigerian female breast cancer patients. Patients and...
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Published in | Anticancer research Vol. 29; no. 5; pp. 1771 - 1776 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Attiki
International Institute of Anticancer Research
01.05.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Background: The relation of nuclear morphometry measurements with clinicopathological features was evaluated along with prognosis
in invasive female breast carcinoma in Libyan patients. Data was compared with corresponding results on Finnish, and Nigerian
female breast cancer patients. Patients and Methods: Histological samples from 131 patients of breast carcinoma were retrospectively
studied by computerized nuclear morphometry. In each case, 50 nuclei were measured and the mean nuclear morphometric features
were calculated and compared with different clinicopathological features, and patient's survival. Results: There was statistically
significant correlation between the mean nuclear area (MNA) and most clinicopathological features, with the strongest association
observed for nuclear grade (p<0.0001). There was also correlation between nuclear area and tumor stage (p<0.04), tumor size
(p<0.03) and lymph node (LN) status (p<0.001). A corresponding relationship was found between other size related features
and clinical factors. The univariate analysis and survival analysis indicated that short survival time was associated with
high nuclear morphometric values. MNA had negative correlation with length of survival (Pearson's test r=-0.29, p=0.019).
Morphometric shape features did not show significant association with clinical features or survival. Conclusion: The results
indicated that nuclear size features are reliable prognostic indicators in Libyan female breast carcinomas, as they were among
Finnish and Nigerian females. The nuclear morphometric parameters can identify the aggressive tumor phenotype and provide
significant prognostic information in predicting survival and tumors at risk of progression. The cut-off (71.0 μm 2 ) of MNA might be applied as quantitative criterium for Libyan nuclear grading to separate patients into good and poor prognosis
groups. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |