Prevalence and clinical significance of antiprothrombin antibodies in patients with systemic lupus erythematosus or with primary antiphospholipid syndrome

• Published in: Haematologica (Roma) Vol. 85; no. 6; pp. 632 - 637
• Main Authors: Munoz-Rodriguez, FJ, Reverter, JC, Font, J, Tassies, D, Cervera, R, Espinosa, G, Carmona, F, Balasch, J, Ordinas, A, Ingelmo, M
• Format: Journal Article
• Language: English
• Published: Pavia Haematologica 01.06.2000
• Subjects: Abortion, Spontaneous - etiology; Adolescent; Adult; Aged; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - epidemiology; Antiphospholipid Syndrome - immunology; Autoantibodies - adverse effects; Autoantibodies - blood; Biological and medical sciences; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - epidemiology; Lupus Erythematosus, Systemic - immunology; Male; Medical sciences; Middle Aged; Miscellaneous. Technology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Plasminogen - metabolism; Pregnancy; Pregnancy Complications, Hematologic - etiology; Prevalence; Prothrombin - immunology; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Thrombocytopenia - etiology; Thrombocytopenia - immunology; Thrombosis - etiology; Thrombosis - immunology; Human; Immunopathology; Connective tissue disease; Skin disease; Correlation; Antiphospholipid antibody syndrome; Prevalence; Clinical form; Biological marker; Cardiovascular disease; Autoimmune disease; Hemopathy; Monoclonal antibody; Case control study; Epidemiology; Vascular disease; Platelet; Systemic disease; Prothrombin; Lupus erythematosus; Disseminated; Technique
• ISSN: 0390-6078; 1592-8721

Systemic Autoimmune Diseases Unit, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS). Hospital Clinic, Barcelona, Spain. BACKGROUND AND OBJECTIVE: Antibodies to prothrombin (aII) have been identified in patients with antiphospholipid antibodies, but their clinical significance is not well known. The aim of our study was to investigate their prevalence and association with clinical manifestations of the antiphospholipid syndrome (APS) in patients with primary APS or with systemic lupus erythematosus (SLE). DESIGN AND METHODS: A series of 177 patients with autoimmune diseases was studied: 70 with primary APS and 107 with systemic lupus erythematosus. A control group of 87 healthy volunteers were included in the study. aII were investigated in sera by an ELISA, using human prothrombin as antigen fixed in irradiated polystyrene plates. RESULTS: aII prevalence in patients with autoimmune disease was 47% (57% and 40% in patients with primary APS or with SLE, respectively) significantly higher than in controls (5%) (p