Biomarkers for Early Detection of Colon Cancer
There is an increasing demand for biomarkers in colon cancer for risk assessment, early detection, prognosis, and surrogate end points. A number of biomarkers have been identified for early detection of colon cancer, although the risk factors have not been identified extensively. The major advances...
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Published in | Clinical cancer research Vol. 7; no. 5; pp. 1118 - 1126 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
American Association for Cancer Research
01.05.2001
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Subjects | |
Online Access | Get full text |
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Summary: | There is an increasing demand for biomarkers in colon cancer for risk assessment, early detection, prognosis, and surrogate
end points. A number of biomarkers have been identified for early detection of colon cancer, although the risk factors have
not been identified extensively. The major advances in understanding colorectal cancer include the identification and the
involvement of APC , p53 , and Ki- ras in the development and progression of the disease, the identification of the aberrant crypt foci as an early preinvasive
lesion, and its relation to the development of cancer. Detecting malignant neoplasms in the early stages offers clinical advantages;
therefore, the National Cancer Institute has established an Early Detection Research Network. The emphasis of the network
is on translational research and collaboration among scientists. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1078-0432 1557-3265 |