Relationship of Ki-ras Mutations in Colon Cancers to Tumor Location, Stage, and Survival: A Population-based Study

Some previous studies have demonstrated significant results between Ki- ras mutations and tumor stage, survival, and/or other clinical variables, whereas others have not. We therefore evaluated the significance of codons 12 and 13 Ki- ras mutations in a large population-based study of 1413 individua...

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Published inCancer epidemiology, biomarkers & prevention Vol. 9; no. 11; pp. 1193 - 1197
Main Authors SAMOWITZ, Wade S, CURTIN, Karen, SCHAFFER, Donna, ROBERTSON, Margaret, LEPPERT, Mark, SLATTERY, Martha L
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.11.2000
Subjects
Adult
Aged
Biological and medical sciences
Codon
Cohort Studies
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
DNA Mutational Analysis
Female
Frameshift Mutation
Gastroenterology. Liver. Pancreas. Abdomen
Genes, ras - genetics
Humans
Male
Medical sciences
Middle Aged
Neoplasm Staging
Prognosis
Sex Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumors
Human
Stage classification
Sex
Malignant tumor
Survival
Colonic disease
Relation
Gene
Epidemiologic genetics
Digestive diseases
Intestinal disease
Genetics
Colon
Mutation
Localization
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Summary:Some previous studies have demonstrated significant results between Ki- ras mutations and tumor stage, survival, and/or other clinical variables, whereas others have not. We therefore evaluated the significance of codons 12 and 13 Ki- ras mutations in a large population-based study of 1413 individuals with colon cancer. Ki- ras mutations were identified in ∼32% of tumors. Codon 12 mutations were significantly more common in proximal than distal tumors (29.1% versus 20.5%; P < 0.01) and in tumors of advanced stage. Tumors from men were more likely to have transition mutations and codon 12 G→A mutations. After adjusting for age and stage, the codon 13 G→A mutation was associated with a 40% (95% confidence interval, 0.95–2.0) increase in short-term mortality from colon cancer. In conclusion, this population-based study demonstrates important relationships between Ki- ras mutations and stage, survival, tumor location, and gender.
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ISSN:1055-9965
1538-7755