Fas-1377A/G and FasL-844 T/C Gene Polymorphisms and Epithelial Ovarian Cancer

• Published in: Anticancer research Vol. 27; no. 2; pp. 991 - 994
• Main Authors: GORMUS, Uzay, ERGEN, Arzu, YILMAZ, Hulya, DALAN, Burak, BERKMAN, Sinan, ISBIR, Turgay
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.03.2007
• Subjects: Adult; Alleles; Biological and medical sciences; Epithelial Cells - pathology; Fas Ligand Protein - genetics; fas Receptor - genetics; Female; Female genital diseases; Genotype; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Middle Aged; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Polymorphism, Single Nucleotide; Tumors; Fas ligand; Ovary carcinoma; Genetic variability; ovarian cancer; Ovary cancer; Genotype; Malignant tumor; Fas/FasL pathway; Female genital diseases; Ovarian diseases; Cancerology; Fas Antigen; Immune privilege; Polymorphism
• ISSN: 0250-7005; 1791-7530

Background: The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain. Ovarian cells are known to exhibit marked FasL immunoreactivity throughout follicular development; there may also be a relationship between Fas and FasL polymorphisms and the immune privileges of the epithelial ovarian cells. Patients and Methods: The study included 47 epithelial ovarian carcinoma patients and 41 healthy subjects. Polymerase chain reaction (PCR) and restriction endonucleases were used to determine the polymorphic Fas and FasL genes. Results: The FasL CC genotype was found to increase the risk of ovarian carcinoma and a protective effect of the GGCT genotype was observed. Conclusion: Because of the expressional aspects of the FasL-844T→C polymorphism, individuals carrying the FasL-844C allele would be expected to have higher FasL expression on tumour cells compared with those carrying the FasL-844T allele. People with such a genotype show a tendency to develop various tumours.