Neoadjuvant Chemotherapy Followed by Limited Surgery in a Mouse Model of Head and Neck Cancer

• Published in: Anticancer research Vol. 29; no. 1; pp. 255 - 259
• Main Authors: JAE JIN LEE, HAH, Jeong-Hun, IM, Seock-Ah, KIM, Si-Young, SUNG, Myung-Whun, KWANG HYUN KIM, DAE SOEG HEO
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.01.2009
• Subjects: Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Biological and medical sciences; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - surgery; Cisplatin - administration & dosage; Disease Progression; Fluorouracil - administration & dosage; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - surgery; Male; Medical sciences; Mice; Mice, Inbred C3H; Neoadjuvant Therapy; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Tumors; Animal model; Prognosis; Rodentia; Malignant tumor; Neoadjuvant treatment; neoadjuvant chemotherapy; Vertebrata; Chemotherapy; radical surgery; Mammalia; Treatment; Cancerology; Mouse; Surgery; ENT disease; Head and neck cancer; limited surgery; Cancer
• ISSN: 0250-7005; 1791-7530

Background: This study evaluated the effect of limited surgery following neoadjuvant chemotherapy compared to radical surgery in SCC VII (squamous cell cancer) tumor-bearing syngeneic C3H/HeJ mice. Materials and Methods: Mice showing a tumor response to cisplatin and 5-fluorouracil therapy were divided into three groups: radical surgery, with a 5 mm margin from the original tumor, group (A); limited surgery of 5 mm margin from the residual tumor, group (B); and very limited surgery with no margin from the residual tumor, group (C). The number of mice was 13 (group A), 12 (group B) and 12 (group C). Results: No recurrence developed except in one mouse in group C. Three mice died in group A, one in group B and one in group C from perioperative complications. By intent-to-treat analysis, the survival was not significantly different among the three groups (p=0.64), or between group A and B (p=0.33). Conclusion: The outcome of limited surgery was comparable to radical surgery after neoadjuvant chemotherapy in the mouse model of head and neck cancer.