Histological Findings in a Human Autogenous Pasteurized Bone Graft

• Published in: Anticancer research Vol. 24; no. 3B; pp. 1893 - 1896
• Main Authors: KUBO, Tadahiko, SUGITA, Takashi, SHIMOSE, Shoji, ARIHIRO, Koji, TANAKA, Haruyuki, NOBUTO, Hiroo, TANAKA, Kumi, OCHI, Mitsuo
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.05.2004
• Subjects: Adult; Biological and medical sciences; Bone Neoplasms - pathology; Bone Neoplasms - surgery; Bone Transplantation - methods; Bone Transplantation - pathology; Chondrosarcoma - pathology; Chondrosarcoma - surgery; Diseases of the osteoarticular system; Humans; Male; Medical sciences; Sterilization; Tibia - pathology; Tibia - surgery; Transplantation, Autologous - methods; Transplantation, Autologous - pathology; Tumors; Tumors of striated muscle and skeleton; Human; Cartilage; Autograft; Chondrosarcoma; Cancerology; Sarcoma; Diseases of the osteoarticular system; Graft; Malignant tumor; Pasteurized hone graft
• ISSN: 0250-7005; 1791-7530

Background: Autogenous bone graft after pasteurization is one of the most valuable procedures for reconstruction of large bone defects following excision of malignant musculoskeletal tumors. To date, there have been no documented histological reports on pasteurized bone grafts, apart from short-term histological results. Case Report: We treated a 27-year-old male with a periosteal chondrosarcoma of the tibia by wide excision and reimplantation of the large pasteurized bone. Biopsy specimens harvested from the pasteurized bone over 3 years after reimplantation were evaluated histologically. The graft cortices remained totally necrotic with empty osseous lacuna, whereas the architecture of the acellular cortical bones was still maintained without microfractures. Deposited seams of woven bone existed focally on the surface of the acellular trabeculae. Conclusion: Our medium-term histological outcome suggests the limitations of incorporating a pasteurized bone graft, but also advocates its role as a useful temporary material for the reconstruction of massive bone defects.