Trophectoderm in control of murine embryonal carcinoma

It has been shown previously that the intact blastocyst of the mouse can regulate tumor formation and colony formation of murine embryonal carcinoma. This effect is consistent with the close histogenetic correspondence between embryonal carcinoma and the inner cell mass of the blastocyst. The abilit...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 44; no. 9; pp. 3987 - 3996
Main Authors BARRY PIERCE, G, AGUILAR, D, HOOD, G, WELLS, R. S
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.09.1984
Subjects
Animals
Biological and medical sciences
Blastocyst - physiology
Cell Division
Cell Line
Cricetinae
Cricetulus
Female
Host-tumor relations. Immunology. Biological markers
Leukemia L1210 - physiopathology
Medical sciences
Melanoma - physiopathology
Mice
Mice, Inbred Strains
Ovary
Teratoma - physiopathology
Tumors
Cell culture
Vertebrata
Regulation(control)
Mammalia
Blastocyst
Rodentia
Tumor
Embryonal carcinoma
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Summary:It has been shown previously that the intact blastocyst of the mouse can regulate tumor formation and colony formation of murine embryonal carcinoma. This effect is consistent with the close histogenetic correspondence between embryonal carcinoma and the inner cell mass of the blastocyst. The ability of inner cell mass, blastocele fluid, and inner and outer surfaces of trophectoderm to abrogate colony formation of a variety of malignant tumors has now been tested. Direct contact of the embryonal carcinoma cells with the blastocele surface of trophectoderm proved to be necessary for abrogation of colony formation of embryonal carcinoma. This effect was not seen with any of the other tumors tested. Some tumors, which lack a normal cellular counterpart in the blastocyst, grew poorly in the blastocele unless a fistula was made in the wall of the blastocyst. Colony formation of the embryonal carcinoma was regulated in blastocysts with fistulas, but the other tumors were not regulated under these conditions. It is concluded that colony formation of embryonal carcinoma cells is regulated by direct contact with the trophectoderm of its corresponding embryonic field in an unknown but specific manner.
ISSN:0008-5472
1538-7445