Identification of human urinary mitoxantrone metabolites

Two polar metabolites of mitoxantrone, a clinically active antitumor agent, have been isolated and purified from the urine of patients by sequential absorption on glass wool and C18-Sep-Pak cartridges followed by preparative high-performance liquid chromatography. Negative ion chemical ionization ma...

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Published inCancer research (Chicago, Ill.) Vol. 46; no. 9; pp. 4858 - 4861
Main Authors CHICCARELLI, F. S, MORRISON, J. A, COSULICH, D. B, PERKINSON, N. A, RIDGE, D. N, SUM, F. W, MURDOCK, K. C, WOODWARD, D. L, ARNOLD, E. T
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.09.1986
Subjects
Anthraquinones - metabolism
Anthraquinones - urine
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Chromatography, High Pressure Liquid
Humans
Mass Spectrometry
Medical sciences
Mitoxantrone
Pharmacology. Drug treatments
Antineoplastic agent
Human
Urine
HPLC chromatography
Identification
Metabolite
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Summary:Two polar metabolites of mitoxantrone, a clinically active antitumor agent, have been isolated and purified from the urine of patients by sequential absorption on glass wool and C18-Sep-Pak cartridges followed by preparative high-performance liquid chromatography. Negative ion chemical ionization mass spectrometry indicated that the two metabolites are the di- and mono-carboxylic acids resulting from oxidation of the terminal hydroxyl groups of the side chain(s). Mass spectral comparison of the urinary metabolites with synthetic compounds confirmed the identification.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0008-5472
1538-7445