Sasa Health Exerts a Protective Effect on Her2/NeuN Mammary Tumorigenesis

Bamboo grass leaves of different Sasa species have been widely used in food and medicine in Eastern Asia for hundreds of years. Of special interest are Kumazasa (Sasa senanensis rehder) leaves used to prepare an alkaline extract known as Sasa Health. This extract was reported to inhibit both the dev...

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Bibliographic Details
Published inAnticancer research Vol. 24; no. 5A; pp. 2879 - 2884
Main Authors MINGQIANG REN, REILLY, R. Todd, SACCHI, Nicoletta
Format Journal Article
LanguageEnglish
Published Attiki International Institute of Anticancer Research 01.09.2004
Subjects
Animals
Biological and medical sciences
Female
Genes, erbB-2
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - growth & development
Mammary Neoplasms, Experimental - genetics
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - prevention & control
Medical sciences
Mice
Mice, Transgenic
Neoplasm Metastasis
Phytotherapy - methods
Plant Extracts - pharmacology
Receptor, ErbB-2 - genetics
Sasa
Tumors
Chemoprophylaxis
Health
Plant leaf
Her2/NeuN
Sasa Health
Carcinogenesis
Prevention
Chemotherapy
Cancerology
Treatment
chemoprevention
Bamboo grass leaves
C-Onc gene
Tumor
mammary tumor
Mammary gland
Protooncogene
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Summary:Bamboo grass leaves of different Sasa species have been widely used in food and medicine in Eastern Asia for hundreds of years. Of special interest are Kumazasa (Sasa senanensis rehder) leaves used to prepare an alkaline extract known as Sasa Health. This extract was reported to inhibit both the development and growth of mammary tumors in a mammary tumor strain of virgin SHN mice (1). We found that Sasa Health exerts a significant protective effect on spontaneous mammary tumorigenesis in another mouse model of human breast cancer, the transgenic FVB-Her2/NeuN mouse model. Two cohorts of Her2/NeuN female mice of different age (eleven-week-old and twenty-four-week-old) chronically treated with Sasa Health in drinking water showed both a delay in the development of tumors and reduced tumor multiplicity. Sasa Health also induced inhibition of mammary duct branching and side bud development in association with reduced angiogenesis. Altogether these findings indicate that Sasa Health contains phytochemicals that can effectively retard spontaneous mammary tumorigenesis.
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ISSN:0250-7005
1791-7530