HIPDM-SPECT Brain Imaging in the Presurgical Evaluation of Patients with Intractable Seizures

• Published in: The Journal of nuclear medicine (1978) Vol. 31; no. 8; pp. 1280 - 1284
• Main Authors: Shen, Wayne, Lee, Byung I, Park, Hee-Myung, Siddiqui, Aslam R, Wellman, Henry H, Worth, Robert M, Markand, Omkar N
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.08.1990; Society of Nuclear Medicine
• Subjects: Adolescent; Adult; Biological and medical sciences; Brain - diagnostic imaging; Brain - surgery; Child; Epilepsies, Partial - diagnostic imaging; Epilepsies, Partial - surgery; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Iodobenzenes; Male; Medical sciences; Temporal Lobe - surgery; Tomography, Emission-Computed, Single-Photon; Radionuclide study; Medical imagery; Nervous system diseases; Photon; Positron emission tomography; Brain (vertebrata)
• ISSN: 0161-5505; 1535-5667

We report the results of interictal and ictal HIPDM-SPECT brain imaging in 34 patients who eventually underwent temporal lobectomy for treatment of medically intractable complex partial seizures. Interictal studies revealed decreased regional cerebral perfusion (rCP) in the temporal lobe corresponding to the eventual site of surgery in 73% of the patients. Similarly, ictal study demonstrated increased rCP in 93% of the patients. In 69% of the patients, the SPECT studies were able to demonstrate both increased rCP on the ictal scan and decreased rCP on the interictal scan in the same location, corresponding to the eventual site of surgery. These results suggest that interictal and ictal SPECT brain imaging can be easily obtained and provide reliable localizing information in the presurgical evaluation of patients with medically intractable epilepsy.