Serum anti-p53 autoantibodies in patients with type 1 diabetes

• Published in: Annals of clinical and laboratory science Vol. 31; no. 3; pp. 253 - 258
• Main Authors: DI CESARE, Enrico, PREVITI, Marcello, LOMBARDO, Fortunato, DI BENEDETTO, Antonino, MAZZU, Nicola, ROMANO, Giacomo, DE LUCA, Filippo, LASCO, Antonio, CUCINOTTA, Domenico
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Philadelphia, PA Institute for Clinical Science 01.07.2001
• Subjects: Adolescent; Adult; Autoantibodies - blood; Biological and medical sciences; Child; Child, Preschool; Diabetes Mellitus, Type 1 - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Immunoglobulin A - blood; Infant; Islets of Langerhans - immunology; Male; Medical sciences; Tumor Suppressor Protein p53 - immunology; Endocrinopathy; Human; Immunopathology; TP53 Gene; Pathogenesis; Autoantibody; Insulin dependent diabetes; Autoimmune disease; Serum; Serology; Quantitative analysis; Tumor suppressor gene
• ISSN: 0091-7370; 1550-8080

The presence of antibodies reacting with the p53 tumor suppressor protein has been described in patients with some autoimmune disorders. In this study we looked for serum anti-p53 antibodies in 64 patients with autoimmune type 1 diabetes mellitus within 4 mo of diagnosis. The presence of anti-p53 antibodies was observed in 6/64 (9.4%) subjects with type 1 diabetes, and in 1/44 (2.3%) subjects with other organ-specific autoimmune diseases (18 primary biliary cirrhosis, 10 autoimmune hepatitis, 16 thyroid diseases), but in none of 45 control subjects. No relationship was found between antibodies directed against islet- and non-islet-specific antigens and anti-p53 antibodies. These findings support a possible role for p53 in some autoimmune disorders.