Lymphoid blastic crisis in Philadelphia chromosome-positive chronic granulocytic leukemia following high-grade non-Hodgkin's lymphoma A case report and review of literature

Istituto di Semeiotica Medica, Universita Cattolica del Sacro Cuore, largo Francesco Vito 1, 00168 Rome, Italy. liviop@osa.net In this paper we describe a case of a 65-year old man with a lymphoid blastic crisis of a chronic granulocytic leukemia occurring seven years after a palatine tonsillar non-...

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Published inHaematologica (Roma) Vol. 85; no. 5; pp. 544 - 547
Main Authors Mele, L, Pagano, L, Equitani, F, Chiusolo, P, Rossi, E, Zini, G, Teofili, L, Leone, G
Format Journal Article
LanguageEnglish
Published Pavia Haematologica 01.05.2000
Subjects
Aged
Biological and medical sciences
Blast Crisis - etiology
Bone Marrow Cells - pathology
Cytogenetics
Fatal Outcome
Fusion Proteins, bcr-abl - genetics
Hematologic and hematopoietic diseases
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - radiotherapy
Male
Medical sciences
Neoplasms, Second Primary
Palatine Tonsil - pathology
Translocation, Genetic
Chromosomal aberration
Human
Antineoplastic agent
Male
Malignant hemopathy
Blast transformation
Non Hodgkin lymphoma
Radiotherapy
Philadelphia chromosome
Case study
Myeloproliferative syndrome
Alkylating agent
Chemotherapy
Chronic
Second cancer
Lymphoproliferative syndrome
Chronic myelocytic leukemia
Abnormal chromosome
Adult
Combined treatment
High malignancy
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Summary:Istituto di Semeiotica Medica, Universita Cattolica del Sacro Cuore, largo Francesco Vito 1, 00168 Rome, Italy. liviop@osa.net In this paper we describe a case of a 65-year old man with a lymphoid blastic crisis of a chronic granulocytic leukemia occurring seven years after a palatine tonsillar non-Hodgkin's lymphoma treated with chemotherapy and radiation therapy. Bone marrow cytogenetic study demonstrated the presence of the typical t(9;22)(q34;q11) and the molecular biology study showed the p210 rearrangement (b2a2). The patient died within a few months, unresponsive to any treatment. This is the first case, described in literature, of a secondary chronic granulocytic leukemia onset with a lymphoid blastic crisis. The authors report the case and a literature review.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ObjectType-Review-1
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ObjectType-Report-2
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ISSN:0390-6078
1592-8721