The intravitreal penetration of orally administered ciprofloxacin in humans

To evaluate the penetration of ciprofloxacin, a new wide-spectrum oral antibiotic, into the vitreous, ciprofloxacin was administered orally to 21 patients who were scheduled to undergo vitreal surgery. Seven patients received 750 mg ciprofloxacin 4 hr before surgery (group I), seven patients receive...

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Published inInvestigative ophthalmology & visual science Vol. 32; no. 8; pp. 2388 - 2392
Main Authors Keren, G, Alhalel, A, Bartov, E, Kitzes-Cohen, R, Rubinstein, E, Segev, S, Treister, G
Format Journal Article
LanguageEnglish
Published Rockville, MD ARVO 01.07.1991
Association for Research in Vision and Ophtalmology
Subjects
Administration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological Assay
Chromatography, High Pressure Liquid
Ciprofloxacin - blood
Ciprofloxacin - pharmacokinetics
Drug Administration Schedule
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Premedication
Random Allocation
Retinal Diseases - surgery
Vitrectomy
Vitreous Body - metabolism
Human
Eye
Antibiotic
Distribution
Oral administration
Vitreous body
Pharmacokinetics
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Summary:To evaluate the penetration of ciprofloxacin, a new wide-spectrum oral antibiotic, into the vitreous, ciprofloxacin was administered orally to 21 patients who were scheduled to undergo vitreal surgery. Seven patients received 750 mg ciprofloxacin 4 hr before surgery (group I), seven patients received this dose 8 hr before surgery (group II), and seven patients received two 750-mg doses of oral ciprofloxacin every 12 hr. The last dose was administered 12 hr before surgery (group III). Vitreous and blood samples were collected simultaneously and assayed for ciprofloxacin concentrations by bioassay and high-performance liquid chromatography.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0146-0404
1552-5783