GSTT1 and GSTM1 Null Genotypes and the Risk of Gastric Cancer: A Case-Control Study in a Chinese Population
Glutathione S -tranferase (GST) enzymes are involved in detoxification of many potentially carcinogenic compounds. The homozygous deletions or null genotypes of GSTT1 (θ class) and GSTM1 (μ class) genes may be associated with an increased risk of cancer. Few studies have evaluated the relationship b...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 9; no. 1; pp. 73 - 80 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
American Association for Cancer Research
01.01.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Glutathione S -tranferase (GST) enzymes are involved in
detoxification of many potentially carcinogenic compounds. The
homozygous deletions or null genotypes of GSTT1
(θ class) and GSTM1 (μ class) genes may be
associated with an increased risk of cancer. Few studies have evaluated
the relationship between GSTT1, GSTM1 and the risk of
gastric cancer, as well as the potential interactions between these
genetic markers and other risk factors of gastric cancer in the Chinese
population. We conducted a case-control study with 143 cases with
gastric cancer, 166 chronic gastritis (CG) cases and 433 cancer-free
population controls from Yangzhong County, China. The
epidemiological data were collected by a standard questionnaire for all
of the subjects, and blood samples were obtained from 91 gastric cancer
cases, 146 CG cases, and 429 controls. GSTT1 and
GSTM1 genotypes were assayed by the PCR method, and
Helicobacter pylori infection was measured by the ELISA
method. Using logistic regression model in SAS, we assessed the
independent effects of GSTT1 and GSTM1
null genotypes on the risk of gastric cancer and their potential
interactions with other factors. The prevalence of GSTM1
null genotype was 48% in gastric cancer cases, 60% in CG patients,
and 51% in controls. The prevalence of GSTT1 null
genotype was 54% in gastric cancer cases, 48% in CG patients, and
46% in controls. After controlling for age, gender, education,
pack-years of smoking, alcohol drinking, body mass index, H.
pylori infection, and fruit and salt intake, the adjusted odds
ratio (OR) for GSTT1 and gastric cancer was 2.50 (95%
confidence interval (CI), 1.01–6.22). When gastric cancer cases were
compared with CG patients, the adjusted OR for GSTT1 was
2.33 (95% CI, 0.75–7.25). However, GSTT1 null genotype
was not associated with the risk of CG when using population controls.
No obvious association was found between GSTM1 and the
risk of both gastric cancer and CG. Our results suggest that
GSTT1 null genotype may be associated with an increased
risk of gastric cancer in a Chinese population. |
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ISSN: | 1055-9965 1538-7755 |