Transposition of the great arteries with aortic arch obstruction. Anatomical review and report of surgical management

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 94; no. 1; pp. 82 - 86
• Main Authors: Pigott, JD, Chin, AJ, Weinberg, PM, Wagner, HR, Norwood, WI
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA AATS/WTSA 01.07.1987; Elsevier
• Subjects: Aorta, Thoracic - pathology; Biological and medical sciences; Cardiology. Vascular system; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Heart; Heart Septal Defects, Ventricular - pathology; Heart Septum - pathology; Humans; Infant; Infant, Newborn; Medical sciences; Myocardium - pathology; Transposition of Great Vessels - pathology; Transposition of Great Vessels - surgery; Human; Aortic coarctation; Concomitant disease; Corrective surgery; Congenital; Malformation; Heart disease; Aorta; Cardiovascular disease; New born; Transposition of the great vessels
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/s0022-5223(19)36321-4

Transposition of the great arteries (S,D,D) is a common congenital cardiovascular malformation that is occasionally associated with ventricular septal defect and left ventricular outflow tract obstruction. Recently right ventricular outflow tract obstruction associated with an aortic arch anomaly has been recognized as an infrequent but important variant of transposition of the great arteries, and this constellation presents a unique surgical challenge. Five infants with this constellation whose systemic circulation was dependent on flow through the ductus arteriosus have undergone definitive surgical treatment with four survivors. An anatomical review of 129 specimens with transposition of the great arteries revealed that 17% had right ventricular outflow tract obstruction and 7% had associated aortic arch obstruction as well. All specimens with aortic arch obstruction and ventricular septal defect except one had a malalignment type ventricular septal defect. Although several treatment options may be considered, recent experience with arterial switch repair in the neonate with transposition of the great arteries (S,D,D) prompted repair in these patients by arterial switch, ventricular septal defect closure, repair of aortic arch obstruction, and augmentation of the right ventricular outflow tract.