Single jejunoileal and right colonic carcinoids as midgut tumors : a study collating immunophenotypes and histogenesis

The jejunoileum and the right colon, both of which are located in the midgut, have some histologic similarities such as the presence of Paneth cells and intraepithelial endocrine cells (IEECs). Since gastrointestinal (GI) carcinoids arise from the same stem cells as GI endocrine cells, the question...

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Bibliographic Details
Published inAnnals of clinical and laboratory science Vol. 25; no. 6; pp. 504 - 512
Main Authors MOYANA, T. N, ZHANG, D, XIANG, J
Format Conference Proceeding Journal Article
LanguageEnglish
Published Philadelphia, PA Institute for Clinical Science 01.11.1995
Subjects
Biological and medical sciences
Carcinoid Tumor - immunology
Carcinoid Tumor - pathology
Chromogranins - analysis
Colonic Neoplasms - immunology
Colonic Neoplasms - pathology
Endocrine Glands - pathology
Epithelium - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Ileal Neoplasms - immunology
Ileal Neoplasms - pathology
Immunophenotyping
Jejunal Neoplasms - immunology
Jejunal Neoplasms - pathology
Medical sciences
Phosphopyruvate Hydratase - analysis
Serotonin - analysis
Silver Staining
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Colonic disease
Human
Origin
Pathology
Similarity
Gut
Digestive diseases
Intestinal disease
Histology
Colon
Malignant tumor
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Summary:The jejunoileum and the right colon, both of which are located in the midgut, have some histologic similarities such as the presence of Paneth cells and intraepithelial endocrine cells (IEECs). Since gastrointestinal (GI) carcinoids arise from the same stem cells as GI endocrine cells, the question was whether or not there might also be similarities in the histogenesis of jejunoileal carcinoids (JICs) and right colonic carcinoids (RCCs). Ten single JICs and 3 RCCs together with their respective controls were stained using various neurohormonal immunoreagents. Our results showed that neither the JICs nor the RCCs appeared to arise from a background of diffuse IEEC hyperplasia. Furthermore, in the jejunoileum, serotonergic progenitor cells appear to have a proclivity for neoplastic transformation, as do cells of the pancreatic polypeptide and glucagon lineage in the right colon.
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ISSN:0091-7370
1550-8080