Hodgkin's disease presenting below the diaphragm. The experience of the Gruppo Italiano Studio Linfomi (GISL)

• Published in: Haematologica (Roma) Vol. 82; no. 6; pp. 676 - 682
• Main Authors: Iannitto, E, Accurso, V, Federico, M, Vallisa, D, Pieresca, C, Gravina, SF, Di Costanzo, F, Di Trapani, R, Silingardi, V, Mariani, G
• Format: Journal Article
• Language: English
• Published: Pavia Haematologica 01.11.1997
• Subjects: Abdominal Neoplasms - pathology; Adolescent; Adult; Aged; Biological and medical sciences; Diaphragm - pathology; Female; Hematologic and hematopoietic diseases; Hodgkin Disease - pathology; Humans; Italy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Prospective Studies; Retroperitoneal Neoplasms - pathology; Splenic Neoplasms - pathology; Italy; Human; Clinical stage; Prognosis; Follow up study; Lymphoproliferative syndrome; Multicenter study; Histological type; Hodgkin disease; Malignant hemopathy; Subphrenic; Lymphoma
• ISSN: 0390-6078; 1592-8721

Ematologia e Centro Trapianto di Midollo, Universita di Palermo, Italy. BACKGROUND AND OBJECTIVE: Infradiaphragmatic Hodgkin's disease is rare, making up 5-12% of cases in clinical stages I and II; consequently, several questions concerning prognosis and treatment strategy remain to be answered. The aim of this study was to analyze the clinical and prognostic characteristics and outcome of this condition. METHODS: A series of 282 patients with CS I-II Hodgkin's disease (HD) was investigated. In 31 patients the disease was confined below the diaphragm (BDHD), and in the remaining above the diaphragm (ADHD). The presenting features and outcomes were compared in the two groups. RESULTS: The BDHD group was older (p