Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium

Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has...

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Bibliographic Details
Published inInvestigative ophthalmology & visual science Vol. 27; no. 3; pp. 364 - 371
Main Authors Penfold, PL, Killingsworth, MC, Sarks, SH
Format Journal Article
LanguageEnglish
Published Bethesda, MD ARVO 01.03.1986
Association for Research in Vision and Ophtalmology
Subjects
Aged
Atrophy
Biological and medical sciences
Female
Humans
Macular Degeneration - pathology
Male
Medical sciences
Ophthalmology
Pigment Epithelium of Eye - pathology
Retina - cytology
Retinopathies
Human
Pathology
Macula
Eye disease
Retinopathy
Atrophia
Pigment epithelium
Retina
Degeneration
Electron microscopy
Elderly
Giant cell
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Summary:Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has not been extensively studied. This paper illustrates at the light and electron microscope level the involvement the atrophic form of SMD. Additional features including pigment clumping and detachment of the retinal pigment epithelium at the advancing edge of the lesion are illustrated. Giant cells and MPS cells are typical features of granulomatous inflammation, and results suggest that they may play a role in the pathogenesis of SMD.
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ISSN:0146-0404
1552-5783