A Rapid Method for Estimating Mean Platelet Survival Time

Platelet survival studies were performed in 27 consecutive subjects, and mean platelet life span was derived by computerized calculations of radioactivity in blood samples obtained daily for 9-11 days. These computer derived estimates were then correlated with the raw whole blood radioactivity data...

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Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 30; no. 9; pp. 1550 - 1553
Main Authors Giuliani, Dennis C, Ford, Edith H, Morse, Bernard S
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.09.1989
Subjects
550601 - Medicine- Unsealed Radionuclides in Diagnostics
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
Blood Platelets - physiology
Blood Vessel Prosthesis
BODY FLUIDS
Cell Survival
COMPUTER CALCULATIONS
Humans
Indium Radioisotopes
MATERIALS
MATHEMATICS
Purpura, Thrombocytopenic - blood
RADIOACTIVITY
RADIOLOGY AND NUCLEAR MEDICINE
Reference Values
REGRESSION ANALYSIS
Software
Splenomegaly - blood
STATISTICS
STEADY-STATE CONDITIONS
SURVIVAL TIME
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Summary:Platelet survival studies were performed in 27 consecutive subjects, and mean platelet life span was derived by computerized calculations of radioactivity in blood samples obtained daily for 9-11 days. These computer derived estimates were then correlated with the raw whole blood radioactivity data obtained for the first 3 days of each study. Data from the 48-hr point correlates with the computer estimates so that platelet survival data can now be reported in 2 days with 93% precision of the long method and without visual curve fitting. Thus, one may take a "quick look" at the probable platelet lifespan, under steady state conditions, in order to evaluate therapy while avoiding problems of patient compliance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0161-5505
1535-5667